Research

Research | Savvas Christoforidis
Home > Research
  • 2022
  • Kotzampasi DM, Premeti K, Papafotika A, Syropoulou V, Christoforidis S, Cournia Z, Leondaritis G. (2022) The orchestrated signaling by PI3Kα and PTEN at the membrane interface Comput Struct Biotechnol J. [Abstract],
  • 2021
  • Papadopoulos C, Fotou E, Moussis V, Ntoyhaniari A, Zografou S, Maltabe V, Kouklis P, Christoforidis S, Tsikaris V. (2021) Intracellular targets: A multiple cargo transporting molecule J Pept Sci. [Abstract],
  • Basagiannis D, Zografou S, Goula E, Gkeka D, Kolettas E, Christoforidis S. (2021) Chemical Inhibitors of Dynamin Exert Differential Effects in VEGF Signaling Cells. [Abstract], 10.3390/cells10050997
  • 2017
  • Basagiannis D, Zografou S, Galanopoulou K, Christoforidis S. (2017) Dynasore impairs VEGFR2 signalling in an endocytosis-independent manner Sci Rep. [Abstract], 10.1038/srep45035.
  • Martzoukou O, Amillis S, Zervakou A, Christoforidis S, Diallinas G. (2017) The AP-2 complex has a specialized clathrin-independent role in apical endocytosis and polar growth in fungi Elife. [Abstract], 10.7554/eLife.20083.
  • Argyros O, Lougiakis N, Kouvari E, Papafotika A, Raptopoulou CP, Psycharis V, Christoforidis S, Pouli N, Marakos P, Tamvakopoulos C. (2017) Design and synthesis of novel 7-aminosubstituted pyrido[2,3-b]pyrazines exhibiting anti-breast cancer activity Eur J Med Chem. [Abstract], 10.1016/j.ejmech.2016.12.025
  • Daniilides K, Lougiakis N, Evangelidis T, Kostakis IK, Pouli N, Marakos P, Mikros E, Skaltsounis AL, Bach S, Baratte B, Ruchaud S, Karamani V, Papafotika A, Christoforidis S, Argyros O, Kouvari E, Tamvakopoulos C. (2017) Discovery of New Aminosubstituted Pyrrolopyrimidines with Antiproliferative Activity Against Breast Cancer Cells and Investigation of their Effect Towards the PI3Kα Enzyme Anticancer Agents Med Chem. [Abstract],
  • 2016
  • Basagiannis D, Zografou S, Murphy C, Fotsis T, Morbidelli L, Ziche M, Bleck C, Mercer J, Christoforidis S. (2016) VEGF induces signalling and angiogenesis by directing VEGFR2 internalisation through macropinocytosis J Cell Sci. [Abstract],
  • Basagiannis D, Christoforidis S. (2016) Constitutive Endocytosis of VEGFR2 Protects the Receptor against Shedding J Biol Chem. [Abstract],
  • Tsolis K.C., Bagli E., Kanaki K., Zografou S., Carpentier S., Bei E.S., Christoforidis S., Zervakis M., Murphy C., Fotsis T., Economou A. (2016) Proteome Changes during Transition from Human Embryonic to Vascular Progenitor Cells J Proteome Res. [Abstract], 10.1021/acs.jproteome.6b00180.
  • 2015
  • Kitsiouli E, Antoniou G, Gotzou H, Karagiannopoulos M, Basagiannis D, Christoforidis S, Nakos G, Lekka ME. (2015) Effect of azithromycin on the LPS-induced production and secretion of phospholipase A2 in lung cells Biochim Biophys Acta. [Abstract], 10.1016/j.bbadis.2015.03.008.
  • 2014
  • Gkeka P, Evangelidis T, Pavlaki M, Lazani V, Christoforidis S, Agianian B, Cournia Z. (2014) Investigating the structure and dynamics of the PIK3CA wild-type and H1047R oncogenic mutant PLoS Comput Biol. [Abstract],
  • Gkeka P, Papafotika A, Christoforidis S, Cournia Z. (2014) Exploring a non-ATP pocket for potential allosteric modulation of PI3Kα J Phys Chem B. [Abstract],
  • 2012
  • Zografou S, Basagiannis D, Papafotika A, Shirakawa R, Horiuchi H, Auerbach D, Fukuda M, Christoforidis S. (2012) A complete Rab screening reveals novel insights in Weibel-Palade body exocytosis J Cell Sci. [Abstract],
  • Sfikas A, Batsi C, Tselikou E, Vartholomatos G, Monokrousos N, Pappas P, Christoforidis S, Tzavaras T, Kanavaros P, Gorgoulis VG, Marcu, KB, Kolettas E. (2012) The canonical NF-κB pathway differentially protects normal and human tumor cells from ROS-induced DNA damage Cell Signal. [Abstract],
  • 2011
  • Papanikolaou A, Papafotika A, Christoforidis S. (2011) CD39 reveals novel insights into the role of transmembrane domains in protein processing, apical targeting and activity Traffic. [Abstract],
  • 2010
  • Boleti H, Smirlis D, Dalagiorgou G, Meurs EF, Christoforidis S, Mavromara P. (2010) ER targeting and retention of the HCV NS4B protein relies on the concerted action of multiple structural features including its transmembrane domains Mol Membr Biol. [Abstract],
  • 2009
  • Batsi C, Markopoulou S, Kontargiris E, Charalambous C, Thomas C, Christoforidis S, Kanavaros P, Constantinou AI, Marcu KB, Kolettas E. (2009) nnBcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation Biochem Pharmacol. [Abstract],
  • 2005
  • Shin HW, Hayashi M, Christoforidis S, Lacas-Gervais S, Hoepfner S, Wenk MR, Modregger J, Uttenweiler-Joseph S, Wilm M, Nystuen A, Frankel WN, Solimena M, De Camilli P, Zerial M. (2005) An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway J Cell Biol. [Abstract],
  • Papanikolaou A, Papafotika A, Murphy C, Papamarcaki T, Tsolas O, Drab M, Kurzchalia TV, Kasper M, Christoforidis S. (2005) Cholesterol-dependent lipid assemblies regulate the activity of the ecto-nucleotidase CD39 J Biol Chem. [Abstract],
  • 2004
  • Karetsou Z, Martic G, Tavoulari S, Christoforidis S, Wilm M, Gruss C, Papamarcaki T. (2004) Prothymosin alpha associates with the oncoprotein SET and is involved in chromatin decondensation FEBS Lett. [Abstract],
  • Schnatwinkel C, Christoforidis S, Lindsay MR, Uttenweiler-Joseph S, Wilm M, Parton RG, Zerial M. (2004) The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms PLoS Biol. [Abstract],
  • Miaczynska M, Christoforidis S, Giner A, Shevchenko A, Uttenweiler-Joseph S, Habermann B, Wilm M, Parton RG, Zerial M. (2004) APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment Cell. [Abstract],
  • 2003
  • Doulias PT, Christoforidis S, Brunk UT, Galaris D. (2003) Endosomal and lysosomal effects of desferrioxamine: protection of HeLa cells from hydrogen peroxide-induced DNA damage and induction of cell-cycle arrest Free Radic Biol Med. [Abstract],
  • 2001
  • Uttenweiler-Joseph S, Neubauer G, Christoforidis S, Zerial M, Wilm M. (2001) Automated de novo sequencing of proteins using the differential scanning technique Proteomics. [Abstract],
  • Christoforidis S, Zerial M. (2001) Purification of EEA1 from bovine brain cytosol using Rab5 affinity chromatography and activity assays Methods Enzymol. [Abstract],
  • 2000
  • Lanzetti L, Rybin V, Malabarba MG, Christoforidis S, Scita G, Zerial M, Di Fiore PP. (2000) The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5 Nature. [Abstract],
  • Nielsen E, Christoforidis S, Uttenweiler-Joseph S, Miaczynska M, Dewitte F, Wilm M, Hoflack B, Zerial M. (2000) Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain J Cell Biol. [Abstract],
  • Christoforidis S, Zerial M. (2000) Purification and identification of novel Rab effectors using affinity chromatography Methods. [Abstract],
  • 1999
  • Christoforidis S, Miaczynska M, Ashman K, Wilm M, Zhao L, Yip SC, Waterfield MD, Backer JM, Zerial M. (1999) Phosphatidylinositol-3-OH kinases are Rab5 effectors Nat Cell Biol. [Abstract],
  • Christoforidis S, McBride HM, Burgoyne RD, Zerial M. (1999) The Rab5 effector EEA1 is a core component of endosome docking Nature. [Abstract],
  • Christoforidis, S, Miaczynska, M, Ashman, K, Wilm, M, Zhao, L, Yip, A-C, Waterfield, MD, Backer, JM, and Zerial, M (1999) Phosphoinositide-3-Kinases are Rab5 effectors. Nature Cell Biol ,
  • 1998
  • Simonsen A, Lippé R, Christoforidis S, Gaullier JM, Brech A, Callaghan J, Toh BH, Murphy C, Zerial M, Stenmark H. (1998) EEA1 links PI(3)K function to Rab5 regulation of endosome fusion Nature. [Abstract],
  • Vitale G, Rybin V, Christoforidis S, Thornqvist P, McCaffrey M, Stenmark H, Zerial M. (1998) Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5 EMBO J. [Abstract],
  • 1996
  • Christoforidis S, Papamarcaki T, and Tsolas O (1996) Human placental ATP diphosphohydrolase is a highly N-glycosylated plasma membrane enzyme. Biochim Biophys Acta ,
  • 1995
  • Christoforidis S, Papamarcaki T, Galaris D, Kellner R, and Tsolas O (1995) Purification and properties of human placental ATP diphosphohydrolase Eur J Biochem ,