2024
- Chalkiadaki K., Statoulla E., Zafeiri M., Voudouri G., Amvrosiadis T., Typou A., Theodoridou N., Moschovas D., Avgeropoulos A., Samiotaki M., Mason J. O. and Gkogkas CG. (2024) GABA/Glutamate neuron differentiation imbalance and increased AKT/mTOR signalling in CNTNAP2-/- cerebral organoids. bioRxiv , https://doi.org/10.1101/2024.04.21.590378
- Chatterjee S, Naeli P, Onar O, Simms N, Garzia A, Hackett A, Coyle K, Harris Snell P, McGirr T, Sawant TN, Dang K, Stoichkova ZV, Azam Y, Saunders MP, Braun M, Alain T, Tuschl T, McDade SS, Longley DB, Gkogkas CG, Adrain C, Knight JRP, Jafarnejad SM. (2024) Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil. Nucleic Acids Res. , 10.1093/nar/gkae849
- Lister KC, Wong C, Uttam S, Parisien M, Stecum P, Brown N, Cai W, Hooshmandi M, Gu N, Amiri M, Beaudry F, Jafarnejad SM, Tavares-Ferreira D, Inturi NN, Mazhar K, Zhao HT, Fitzsimmons B, Gkogkas CG, Sonenberg N, Price TJ, Diatchenko L, Atlasi Y, Mogil JS, Khoutorsky A. (2024) Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain. bioRxiv , 10.1101/2024.06.24.600539.
2023
- Wong C, Tavares-Ferreira D, Thörn Perez C, Sharif B, Uttam S, Amiri M, Lister KC, Hooshmandi M, Nguyen V, Séguéla P, Sonenberg N, Price TJ, Gkogkas CG* and Khoutorsky A.* (2023) 4E-BP1-dependent translation in nociceptors controls mechanical hypersensitivity via TRIM32/type I interferon signaling. Sci Adv. , 10.1126/sciadv.adh9603. *co-last author
- Hooshmandi M, Sharma V, Thörn Perez C, Sood R, Krimbacher K, Wong C, Lister KC, Ureña Guzmán A, Bartley TD, Rocha C, Maussion G, Nadler E, Roque PM, Gantois I, Popic J, Lévesque M, Kaufman RJ, Avoli M, Sanz E, Nader K, Hagerman RJ, Durcan TM, Costa-Mattioli M, Prager-Khoutorsky M, Lacaille JC, Martinez-Cerdeno V, Gibson JR, Huber KM, Sonenberg N*, Gkogkas CG*, Khoutorsky A*. (2023) Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome. Neuron , 10.1016/j.neuron.2023.06.017 *co-last author
- Chalkiadaki K., Statoulla E., Zafeiri M., Haji N., Lacaille J.C., Powell C.M., Jafarnejad S.M., Khoutorsky A., Gkogkas C. G. (2023) Reversal of memory and autism-related phenotypes in Tsc2+/- mice via inhibition of Nlgn1. Front Cell Dev Biol , 10.3389/fcell.2023.1205112
- Patil S, Chalkiadaki K, Mergiya TF, Krimbacher K, Amorim IS, Akerkar S, Gkogkas CG*, Bramham CR*. (2023) eIF4E phosphorylation recruits β-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenance. iScience , 10.1016/j.isci.2023.106649
- Anadolu MN, Sun J, Kailasam S, Chalkiadaki K, Krimbacher K, Li JT, Markova T, Jafarnejad SM, Lefebvre F, Ortega J, Gkogkas CG, Sossin WS. (2023) Ribosomes in RNA Granules Are Stalled on mRNA Sequences That Are Consensus Sites for FMRP Association J Neurosci , 10.1523/JNEUROSCI.1002-22.2023
2022
- Liu D, Nanclares C, Simbriger K, Fang K, Lorsung E, Le N, Amorim IS, Chalkiadaki K, Pathak SS, Li J, Gewirtz JC, Jin VX, Kofuji P, Araque A, Orr HT, Gkogkas CG, Cao R. (2022) Autistic-like behavior and cerebellar dysfunction in Bmal1 mutant mice ameliorated by mTORC1 inhibition Mol Psychiatry. [Abstract],
- Tansley S, Gu N, Guzmán AU, Cai W, Wong C, Lister K, Muñoz-Pino E, Yousefpour N, Roome RB, Heal J, Wu N, Castonguay A, Lean G, Muir EM, Kania A, Prager-Khoutorsky M, Zhang J, Gkogkas CG, Fawcett JW, Diatchenko L, Ribeiro-da-Silva A, De Koninck Y, Mogil JS (2022) Microglia-mediated degradation of perineuronal nets promotes pain Science. [Abstract],
- Chalkiadaki K, Hooshmandi M, Lach G, Statoulla E, Simbriger K, Amorim IS, Kouloulia S, Zafeiri M, Pothos P, Bonneil É, Gantois I, Popic J, Kim SH, Wong C, Cao R, Komiyama NH, Atlasi Y, Jafarnejad SM, Khoutorsky A, Gkogkas CG. (2022) Mnk1/2 kinases regulate memory and autism-related behaviours via Syngap1 Brain. [Abstract],
2021
- Roque PS, Hooshmandi M, Neagu-Lund L, Yin S, Yousefpour N, Sato H, Sato T, Nakadate Y, Kawakami A, Tahmasebi S, Ribeiro-da-Silva A, Gkogkas CG, Prager-Khoutorsky M, Schricker T, Wykes L, Khoutorsky A. (2021) Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1 Sci Rep. [Abstract],
- Statoulla E, Chalkiadaki K, Karozis D, Gkogkas CG. (2021) Regulation of mRNA translation in stem cells; links to brain disorders Cell Signal. [Abstract],
- Chalkiadaki K, Statoulla E, Markou M, Bellou S, Bagli E, Fotsis T, Murphy C, Gkogkas CG. (2021) Translational control in neurovascular brain development R Soc Open Sci. [Abstract],
- Hooshmandi M, Truong VT, Fields E, Thomas RE, Wong C, Sharma V, Gantois I, Soriano Roque P, Chalkiadaki K, Wu N, Chakraborty A, Tahmasebi S, Prager-Khoutorsky M, Sonenberg N, Suvrathan A, Watt AJ, Gkogkas CG, Khoutorsky A. (2021) 4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors Cell Rep. [Abstract],
2020
- Simbriger K, Amorim IS, Lach G, Chalkiadaki K, Kouloulia S, Jafarnejad SM, Khoutorsky A and Gkogkas C. G. (2020) Uncovering memory-related gene expression in contextual fear conditioning using ribosome profiling. Prog Neurobiol , 10.1016/j.pneurobio.2020.101903.
- Atlasi Y, Jafarnejad SM, Gkogkas C. G., Vermeulen M, Sonenberg N, Stunnenberg HG. (2020) The translational landscape of ground state pluripotency Nat Commun , 10.1038/s41467-020-15449-9
2019
- Hoang HD, Graber TE, Jia JJ, Vaidya N, Gilchrist VH, Xiang X, Li W, Cowan KN, Gkogkas C. G., Jaramillo M, Jafarnejad SM, Alain T. (2019) Induction of an Alternative mRNA 5' Leader Enhances Translation of the Ciliopathy Gene Inpp5e and Resistance to Oncolytic Virus Infection. Cell Rep , 10.1016/j.celrep.2019.11.072
- Kouloulia S, Hallin EI, Simbriger K, Amorim IS, Lach G, Amvrosiadis T, Chalkiadaki K, Kampaite A, Truong VT, Hooshmandi M, Jafarnejad SM, Skehel P, Kursula P, Khoutorsky A and Gkogkas C. G. (2019) Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity. Cell Rep , 10.1016/j.celrep.2019.11.023
- Simbriger K, Amorim IS, Chalkiadaki K, Lach G, Jafarnejad SM, Khoutorsky A and Gkogkas C. G. (2019) Monitoring translation in synaptic fractions using a ribosome profiling strategy. J Neurosci Methods. , 10.1016/j.jneumeth.2019.108456
2018
- Amorim IS, Lach G and Gkogkas CG. (2018) The Role of the Eukaryotic Translation Initiation Factor 4E (eIF4E) in Neuropsychiatric Disorders. Front Genet. , 10.3389/fgene.2018.00561
- Uttam, S., Wong, C, Amorim, I. S., Jafarnejad, S. M., Tansley, S., Yang, J., Prager-Khoutorsky, M., Mogil, J. S., Gkogkas, C. G.* and Khoutorsky, A.* (2018) Translational profiling of dorsal root ganglia and spinal cord in a mouse model of neuropathic pain. Neurobiology of pain , 10.1016/j.ynpai.2018.04.001
- Amorim I.S., Kedia S., Kouloulia S., Simbriger K., Gantois I., Jafarnejad S. M., Li Y., Kampaite A., Pooters T., Romanò N and Gkogkas C. G. (2018) Loss of eIF4E phosphorylation engenders depression-like behaviors via selective mRNA translation. The Journal of neuroscience : the official journal of the Society for Neuroscience 21 , 10.1523/JNEUROSCI.2673-17.2018
- Jafarnejad, S. M., Chapat, C., Matta-Camacho, E., Gelbart, I. A., Hesketh, G. G., Arguello, M., Garzia, A., Kim, S. H., Attig, J., Shapiro, M., Morita, M., Khoutorsky, A., Alain, T., Gkogkas, C., Stern-Ginossar, N., Tuschl, T., Gingras, A. C., Duchaine, T (2018) Translational control of ERK signaling through miRNA/4EHP-directed silencing. Elife 7 , 10.7554/eLife.35034
2017
- Martin, L. J., Smith, S. B., Khoutorsky, A., Magnussen, C. A., Samoshkin, A., Sorge, R. E., Cho, C., Yosefpour, N., Sivaselvachandran, S., Tohyama, S., Cole, T., Khuong, T. M., Mir, E., Gibson, D. G., Wieskopf, J. S., Sotocinal, S. G., Austin, J. S., Meloto, C. B., Gitt, J. H., Gkogkas, C., Sonenberg, N., Greenspan, J. D., Fillingim, R. B., Ohrbach, R., Slade, G. D., Knott, C., Dubner, R., Nackley, A. G., Ribeiro-da-Silva, A., Neely, G. G., Maixner, W., Zaykin, D. V., Mogil, J. S. & Diatchenko, L. (2017) Epiregulin and EGFR interactions are involved in pain processing. J Clin Invest 127 , 10.1172/JCI87406
- Moy, J. K., Khoutorsky, A., Asiedu, M. N., Black, B. J., Kuhn, J. L., Barragan-Iglesias, P., Megat, S., Burton, M. D., Burgos-Vega, C. C., Melemedjian, O. K., Boitano, S., Vagner, J., Gkogkas, C. G., Pancrazio, J. J., Mogil, J. S., Dussor, G., Sonenberg, (2017) he MNK-eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain. The Journal of neuroscience : the official journal of the Society for Neuroscience 37 , 10.1523/JNEUROSCI.0220-17.2017
- Gantois, I., Khoutorsky, A., Popic, J., Aguilar-Valles, A., Freemantle, E., Cao, R., Sharma, V., Pooters, T., Nagpal, A., Skalecka, A., Truong, V. T., Wiebe, S., Groves, I. A., Jafarnejad, S. M., Chapat, C., McCullagh, E. A., Gamache, K., Nader, K., Lacaille, J. C., Gkogkas, C. G.* & Sonenberg, N.* (2017) Metformin ameliorates core deficits in a mouse model of fragile X syndrome. Nature medicine 23 , 10.1038/nm.4335
- Tuttle, A. H., Tansley, S., Dossett, K., Tohyama, S., Khoutorsky, A., Maldonado-Bouchard, S., Stein, L., Gerstein, L., Crawhall-Duk, H., Pearl, R., Sukosd, M., Leger, P., Hardt, O. M., Yachnin, D., Austin, J. S., Chan, C. M., Pooters, T., Groves, I., Martin, L. J., Sonenberg, N., Gkogkas, C. G.* & Mogil, J. S.* (2017) Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes. Proceedings of the National Academy of Sciences of the United States of America 114 , 10.1073/pnas.1703477114
- Chapat, C., Jafarnejad, S. M., Matta-Camacho, E., Hesketh, G. G., Gelbart, I. A., Attig, J., Gkogkas, C. G., Alain, T., Stern-Ginossar, N., Fabian, M. R., Gingras, A. C., Duchaine, T. F. & Sonenberg, N. (2017) Cap-binding protein 4EHP effects translation silencing by microRNAs. Proceedings of the National Academy of Sciences of the United States of America , 10.1073/pnas.1701488114
2016
- Tahmasebi S., Jafarnejad S. M., Tam I. S., Gonatopoulos-Pournatzis T., Matta-Camacho E., Tsukumo Y., Yanagiya A., Li W., Atlasi Y., Caron M., Braunschweig U., Pearl D., Khoutorsky A., Gkogkas C. G., Nadon R., Bourque G., Yang X. J., Tian B., Stunnenberg H (2016) Control of embryonic stem cells self-renewal and differentiation via coordinated splicing and translation of YY2. PNAS , 10.1073/pnas.1615540113
- Khoutorsky, A., Sorge R.E., Prager-Khoutorsky M., Pawlowski S. A., Longod G., Jafarnejad S. M., Tahmasebi S., Martin L., Pitchere M. H., Gkogkas C. G., Sharif-Naeinig R., Alfredo Ribeiro-da-Silvad A., Bourque C. W., Cerveroh F., Mogil J. S., & Sonenberg N (2016) eIF2alpha phosphorylation controls thermal nociception PNAS , 10.1073/pnas.1614047113
- Skalecka, A., Liszewska, E., Bilinski, R., Gkogkas, C., Khoutorsky, A., Malik, A. R., Sonenberg, N. & Jaworski, J. (2016) mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons Dev Neurobiol , 10.1002/dneu.22392
2015
- Khoutorsky, A., Bonin, R. P., Sorge, R. E., Gkogkas, C. G., Pawlowski, S. A., Jafarnejad, S. M., Pitcher, M. H., Alain, T., Perez-Sanchez, J., Salter, E. W., Martin, L., Ribeiro-da-Silva, A., De Koninck, Y., Cervero, F., Mogil, J. S. & Sonenberg, N. (2015) Translational control of nociception via 4E-binding protein 1 Elife 4 , 10.7554/eLife.12002
- Maity, S., Rah, S., Sonenberg, N., Gkogkas, C. G. & Nguyen, P. V. (2015) Norepinephrine triggers metaplasticity of LTP by increasing translation of specific mRNAs. Learn Mem 22 , 10.1101/lm.039222.115
- Aguilar-Valles, A., Matta-Camacho, E., Khoutorsky, A., Gkogkas, C., Nader, K., Lacaille, J. C. & Sonenberg, N. (2015) Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2. The Journal of neuroscience : the official journal of the Society for Neuroscience 35 , 10.1523/JNEUROSCI.4615-14.2015
- Cao, R., Gkogkas, C. G., de Zavalia, N., Blum, I. D., Yanagiya, A., Tsukumo, Y., Xu, H., Lee, C., Storch, K. F., Liu, A. C., Amir, S. & Sonenberg, N. (2015) Light-regulated translational control of circadian behavior by eIF4E phosphorylation. Nature Neuroscience 18 , 10.1038/nn.4010
- Aulas, A., Caron, G., Gkogkas, C. G., Mohamed, N. V., Destroismaisons, L., Sonenberg, N., Leclerc, N., Parker, J. A. & Vande Velde, C. (2015) G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA. J Cell Biol 209 , 10.1083/jcb.201408092
2014
- Gkogkas, C. G., Khoutorsky, A., Cao, R., Jafarnejad, S. M., Prager-Khoutorsky, M., Giannakas, N., Kaminari, A., Fragkouli, A., Nader, K., Price, T. J., Konicek, B. W., Graff, J. R., Tzinia, A. K., Lacaille, J. C. & Sonenberg, N. (2014) Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes Cell reports 9 , 10.1016/j.celrep.2014.10.064
- Jung, H., Gkogkas, C. G., Sonenberg, N. & Holt, C. E. (2014) Remote control of gene function by local translation. Cell 157 , 10.1016/j.cell.2014.03.005
- Tahmasebi, S., Alain, T., Rajasekhar, V. K., Zhang, J. P., Prager-Khoutorsky, M., Khoutorsky, A., Dogan, Y., Gkogkas, C. G., Petroulakis, E., Sylvestre, A., Ghorbani, M., Assadian, S., Yamanaka, Y., Vinagolu-Baur, J. R., Teodoro, J. G., Kim, K., Yang, X. J. & Sonenberg, N. (2014) Multifaceted regulation of somatic cell reprogramming by mRNA translational control. Cell Stem Cell 14 , 10.1016/j.stem.2014.02.005
2013
- Gkogkas, C. G. & Sonenberg, N. (2013) Translational control and autism-like behaviors. Cell Logist 3 , 10.4161/cl.24551
- Cao, R., Robinson, B., Xu, H., Gkogkas, C., Khoutorsky, A., Alain, T., Yanagiya, A., Nevarko, T., Liu, A. C., Amir, S. & Sonenberg, N. (2013) Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling. Neuron 79 , 10.1016/j.neuron.2013.06.026
- Khoutorsky, A., Gkogkas, C. G.*, Yanagiya, A.*, Fabian, M. R., Prager-Khoutorsky, M., Cao, R., Gamache, K., Bouthiette, F., Parsyan, A., Sorge, R. E., Mogil, J. S., Nader, K., Lacaille, J. C. & Sonenberg, N. (2013) Control of synaptic plasticity and memory via suppression of poly(A)-binding protein. Control of synaptic plasticity and memory via suppression of poly(A)-binding protein. , 10.1016/j.neuron.2013.02.025
- Ran, I., Gkogkas, C. G., Vasuta, C., Tartas, M., Khoutorsky, A., Laplante, I., Parsyan, A., Nevarko, T., Sonenberg, N. & Lacaille, J. C. (2013) Selective regulation of GluA subunit synthesis and AMPA receptor-mediated synaptic function and plasticity by the translation repressor 4E-BP2 in hippocampal pyramidal cells. The Journal of neuroscience : the official journal of the Society for Neuroscience 33 , 10.1523/JNEUROSCI.3264-12.2013
- Gkogkas, C. G., Khoutorsky, A., Ran, I., Rampakakis, E., Nevarko, T., Weatherill, D. B., Vasuta, C., Yee, S., Truitt, M., Dallaire, P., Major, F., Lasko, P., Ruggero, D., Nader, K., Lacaille, J. C. & Sonenberg, N. (2013) Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature 493 , 10.1038/nature11628
2012
- Chua, J. J., Schob, C., Rehbein, M., Gkogkas, C. G., Richter, D. & Kindler, S. (2012) Synthesis of two SAPAP3 isoforms from a single mRNA is mediated via alternative translational initiation. Sci Rep 2 , 10.1038/srep00484
2011
- Parsyan, A., Svitkin, Y., Shahbazian, D., Gkogkas, C., Lasko, P., Merrick, W. C. & Sonenberg, N. (2011) mRNA helicases: the tacticians of translational control. Nat Rev Mol Cell Biol 12 , 10.1038/nrm3083
- Gkogkas, C., Wardrope, C., Hannah, M. & Skehel, P. (2011) The ALS8-associated mutant VAPB(P56S) is resistant to proteolysis in neurons. J Neurochem 117 , 10.1111/j.1471-4159.2011.07201.x
2010
- Gkogkas, C., Sonenberg, N. & Costa-Mattioli, M. (2010) Translational control mechanisms in long-lasting synaptic plasticity and memory J Biol Chem 285 , 10.1074/jbc.R110.154476
- Bidinosti, M., Ran, I., Sanchez-Carbente, M. R., Martineau, Y., Gingras, A. C., Gkogkas, C., Raught, B., Bramham, C. R., Sossin, W. S., Costa-Mattioli, M., DesGroseillers, L., Lacaille, J. C. & Sonenberg, N. (2010) Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission. Mol Cell 37 , 10.1016/j.molcel.2010.02.022
- Rampakakis, E., Gkogkas, C., Di Paola, D. & Zannis-Hadjopoulos, M. (2010) Replication initiation and DNA topology: The twisted life of the origin. J Cell Biochem 110 , 10.1002/jcb.22557
2008
- Gkogkas, C., Middleton, S., Kremer, A. M., Wardrope, C., Hannah, M., Gillingwater, T. H. & Skehel, P. (2008) VAPB interacts with and modulates the activity of ATF6 Hum Mol Genet 17 , 10.1093/hmg/ddn040
2003
- Gkogkas, C. G.*, Vernikos, G. S.*, Promponas, V. J. & Hamodrakas, S. J. (2003) GeneViTo: visualizing gene-product functional and structural features in genomic datasets. BMC Bioinformatics 4 , 10.1186/1471-2105-4-53
