Research

Research | Evangelos Kolettas
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  • 2022
  • Foutadakis S, Roupakia E, Liakopoulos P, Kolovos P, Kolettas E. (2022) An Expanded Interplay Network between NF-κB p65 (RelA) and E2F1 Transcription Factors: Roles in Physiology and Pathology Cancers (Basel). [Abstract],
  • 2021
  • Roupakia E, Chavdoula E, Karpathiou G, Vatsellas G, Chatzopoulos D, Mela A, Gillette JM, Kriegsmann K, Kriegsmann M, Batistatou A, Goussia A, Marcu KB, Karteris E, Klinakis A, Kolettas E. (2021) Canonical NF-κB Promotes Lung Epithelial Cell Tumour Growth by Downregulating the Metastasis Suppressor CD82 and Enhancing Epithelial-to-Mesenchymal Cell Transition Cancers (Basel). [Abstract],
  • Roupakia E, Markopoulos GS, Kolettas E. (2021) Genes and pathways involved in senescence bypass identified by functional genetic screens Mech Ageing Dev. [Abstract],
  • Diamantis D, Agalou A, Chatziathanasiadou MV, Markopoulos GS, Bellou S, Kanaki Z, Crook T, Syed N, Rampias T, Klinakis A, Kolettas E, Beis D, Tzakos AG (2021) Biotin-Yellow a biotin guided NIR turn-on fluorescent probe for cancer targeted diagnosis Sensors and Actuators B: , https://doi.org/10.1016/j.snb.2021.129807
  • Basagiannis D, Zografou S, Goula E, Gkeka D, Kolettas E, Christoforidis S. (2021) Chemical Inhibitors of Dynamin Exert Differential Effects in VEGF Signaling Cells. [Abstract], 10.3390/cells10050997
  • 2020
  • Ntellas P, Mavroeidis L, Gkoura S, Gazouli I, Amylidi AL, Papadaki A, Zarkavelis G, Mauri D, Karpathiou G, Kolettas E, Batistatou A, Pentheroudakis G. (2020) Old Player-New Tricks: Non Angiogenic Effects of the VEGF/VEGFR Pathway in Cancer Cancers (Basel). [Abstract],
  • Tsiailanis AD, Renziehausen A, Kiriakidi S, Vrettos EI, Markopoulos GS, Sayyad N, Hirmiz B, Aguilar MI, Del Borgo MP, Kolettas E, Widdop RE, Mavromoustakos T, Crook T, Syed N, Tzakos AG. (2020) Enhancement of glioblastoma multiforme therapy through a novel Quercetin-Losartan hybrid Free Radic Biol Med. [Abstract],
  • 2019
  • Chavdoula E, Habiel DM, Roupakia E, Markopoulos GS, Vasilaki E, Kokkalis A, Polyzos AP, Boleti H, Thanos D, Klinakis A, Kolettas E, Marcu KB. (2019) CHUK/IKK-α loss in lung epithelial cells enhances NSCLC growth associated with HIF up-regulation Life Sci Alliance. [Abstract],
  • Markopoulos GS, Roupakia E, Marcu KB, Kolettas E. (2019) Epigenetic Regulation of Inflammatory Cytokine-Induced Epithelial-To-Mesenchymal Cell Transition and Cancer Stem Cell Generation Cells. [Abstract],
  • Sundar D, Yu Y, Katiyar SP, Putri JF, Dhanjal JK, Wang J, Sari AN, Kolettas E, Kaul SC, Wadhwa R. (2019) Wild type p53 function in p53 Y220C mutant harboring cells by treatment with Ashwagandha derived anticancer withanolides: bioinformatics and experimental evidence J Exp Clin Cancer Res. [Abstract],
  • 2018
  • Patounas O, Papacharalampous I, Eckerich C, Markopoulos GS, Kolettas E, Fackelmayer FO. (2018) A novel splicing isoform of protein arginine methyltransferase 1 (PRMT1) that lacks the dimerization arm and correlates with cellular malignancy J Cell Biochem. [Abstract],
  • Roupakia E, Markopoulos G and Kolettas E (2018) IL-12-mediated transcriptional regulation of matrix metalloproteinases. Bioscience Rep ,
  • Markopoulos GS, Roupakia E, Tokamani M, Alabasi G, Sandaltzopoulos R, Marcu KB, Kolettas E. (2018) Roles of NF-κB Signaling in the Regulation of miRNAs Impacting on Inflammation in Cancer Biomedicines. [Abstract],
  • Ypsilantis K , Plakatouras JC , Manos MJ , Kourtellaris A , Markopoulos G , Kolettas E , Garoufis A . (2018) Stepwise synthesis, characterization, DNA binding properties and cytotoxicity of diruthenium oligopyridine compounds conjugated with peptides Dalton Trans. [Abstract],
  • 2017
  • Markopoulos GS, Roupakia E, Tokamani M, Vartholomatos G, Tzavaras T, Hatziapostolou M, Fackelmayer FO, Sandaltzopoulos R, Polytarchou C, Kolettas E. (2017) Senescence-associated microRNAs target cell cycle regulatory genes in normal human lung fibroblasts Exp Gerontol. [Abstract],
  • Markopoulos GS, Roupakia E, Tokamani M, Chavdoula E, Hatziapostolou M, Polytarchou C, Marcu KB, Papavassiliou AG, Sandaltzopoulos R, Kolettas E. (2017) A step-by-step microRNA guide to cancer development and metastasis Cell Oncol (Dordr). [Abstract],
  • 2016
  • Markopoulos G, Noutsopoulos D, Mantziou S, Gerogiannis D, Thrasyvoulou S, Vartholomatos G, Kolettas E, Tzavaras T. (2016) Genomic analysis of mouse VL30 retrotransposons Mob DNA. [Abstract],
  • 2014
  • Primikyri A, Chatziathanasiadou MV, Karali E, Kostaras E, Mantzaris MD, Hatzimichael E, Shin JS, Chi SW, Briasoulis E, Kolettas E, Gerothanassis IP, Tzakos AG. (2014) Direct binding of Bcl-2 family proteins by quercetin triggers its pro-apoptotic activity ACS Chem Biol. [Abstract],
  • 2012
  • Sfikas A, Batsi C, Tselikou E, Vartholomatos G, Monokrousos N, Pappas P, Christoforidis S, Tzavaras T, Kanavaros P, Gorgoulis VG, Marcu, KB, Kolettas E. (2012) The canonical NF-κB pathway differentially protects normal and human tumor cells from ROS-induced DNA damage Cell Signal. [Abstract],
  • Konisti S, Mantziou S, Markopoulos G, Thrasyvoulou S, Vartholomatos G, Sainis I, Kolettas E, Noutsopoulos D, Tzavaras T. (2012) H2O2 signals via iron induction of VL30 retrotransposition correlated with cytotoxicity Free Radic Biol Med. [Abstract],
  • 2011
  • Sideridou M, Zakopoulou R, Evangelou K, Liontos M, Kotsinas A, Rampakakis E, Gagos S, Kahata K, Grabusic K, Gkouskou K, Trougakos IP, Kolettas E, Georgakilas AG, Volarevic S, Eliopoulos AG, Zannis-Hadjopoulos M, Moustakas A, Gorgoulis VG. (2011) Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins J Cell Biol. [Abstract],
  • 2010
  • Sigala F, Savvari P, Liontos M, Sigalas P, Pateras IS, Papalampros A, Basdra EK, Kolettas E, Papavassiliou AG, Gorgoulis VG. (2010) Increased expression of bFGF is associated with carotid atherosclerotic plaques instability engaging the NF-κB pathway J Cell Mol Med. [Abstract],
  • Noutsopoulos D, Markopoulos G, Vartholomatos G, Kolettas E, Kolaitis N, Tzavaras T. (2010) VL30 retrotransposition signals activation of a caspase-independent and p53-dependent death pathway associated with mitochondrial and lysosomal damage Cell Res. [Abstract],
  • 2009
  • Batsi C, Markopoulou S, Kontargiris E, Charalambous C, Thomas C, Christoforidis S, Kanavaros P, Constantinou AI, Marcu KB, Kolettas E. (2009) nnBcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation Biochem Pharmacol. [Abstract],
  • Markopoulou S, Kontargiris E, Batsi C, Tzavaras T, Trougakos I, Boothman DA, Gonos ES, Kolettas E. (2009) Vanadium-induced apoptosis of HaCaT cells is mediated by c-fos and involves nuclear accumulation of clusterin FEBS J. [Abstract],
  • Batsi C, Markopoulou S, Vartholomatos G, Georgiou I, Kanavaros P, Gorgoulis VG, Marcu KB, Kolettas E. (2009) Chronic NF-kappaB activation delays RasV12-induced premature senescence of human fibroblasts by suppressing the DNA damage checkpoint response Mech Ageing Dev. [Abstract],
  • 2007
  • Barbouti A, Amorgianiotis C, Kolettas E, Kanavaros P, Galaris D. (2007) Hydrogen peroxide inhibits caspase-dependent apoptosis by inactivating procaspase-9 in an iron-dependent manner Free Radic Biol Med. [Abstract],
  • Noutsopoulos D, Markopoulos G, Koliou M, Dova L, Vartholomatos G, Kolettas E, Tzavaras T. (2007) Vanadium induces VL30 retrotransposition at an unusually high level: a possible carcinogenesis mechanism J Mol Biol. [Abstract],
  • 2006
  • Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou LV, Kolettas E, Niforou K, Zoumpourlis VC, Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, Sehested M, Andersen CL, Dyrskjot L, Ørntoft T, Lukas J, Kittas C, Helleday T, (2006) Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints Nature. [Abstract],
  • Kolettas E, Thomas C, Leneti E, Skoufos I, Mbatsi C, Sisoula C, Manos G, Evangelou A. (2006) Rosmarinic acid failed to suppress hydrogen peroxide-mediated apoptosis but induced apoptosis of Jurkat cells which was suppressed by Bcl-2 Mol Cell Biochem. [Abstract],
  • Kolettas E, Skoufos I, Kontargiris E, Markopoulou S, Tzavaras T, Gonos ES. (2006) Bcl-2 but not clusterin/apolipoprotein J protected human diploid fibroblasts and immortalized keratinocytes from ceramide-induced apoptosis: role of p53 in the ceramide response Arch Biochem Biophys. [Abstract],
  • 2004
  • Kontargiris E, Kolettas E, Vadalouca A, Trougakos IP, Gonos ES, Kalfakakou V. (2004) Ectopic expression of clusterin/apolipoprotein J or Bcl-2 decreases the sensitivity of HaCaT cells to toxic effects of ropivacaine Cell Res. [Abstract],
  • 2002
  • Assimakopoulos D, Kolettas E, Patrikakos G, Evangelou A. (2002) The role of CD44 in the development and prognosis of head and neck squamous cell carcinomas Histol Histopathol. [Abstract],
  • Gonos ES, Agrafiotis D, Dontas AS, Efthimiopoulos S, Galaris D, Karamanos NK, Kletsas D, Kolettas E, Panayotou G, Pratsinis H, Sekeri-Pataryas KE, Simoes D, Sourlingas TG, Stathakos D, Stratigos AJ, Tavernarakis N, Trougakos IP, Tsiganos CP, Vynios DH. (2002) Ageing research in Greece Exp Gerontol. [Abstract],
  • Barradas M, Gonos ES, Zebedee Z, Kolettas E, Petropoulou C, Delgado MD, León J, Hara E, Serrano M. (2002) Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence Exp Cell Res. [Abstract],
  • 2001
  • Petropoulou C, Trougakos IP, Kolettas E, Toussaint O, Gonos ES. (2001) Clusterin/apolipoprotein J is a novel biomarker of cellular senescence that does not affect the proliferative capacity of human diploid fibroblasts FEBS Lett. [Abstract],
  • Kolettas E, Muir HI, Barrett JC, Hardingham TE. (2001) Chondrocyte phenotype and cell survival are regulated by culture conditions and by specific cytokines through the expression of Sox-9 transcription factor Rheumatology (Oxford). [Abstract],
  • Paschos I, Natsis L, Nathanailides C, Kagalou I, Kolettas E. (2001) Induction of gynogenesis and androgenesis in goldfish Carassius auratus (var. oranda) Reprod Domest Anim. [Abstract],
  • Kolettas E, Evangelou A, Gonos ES. (2001) v-FBR-fos oncogene fails to rescue mammalian cells from growth arrest but affects the responses of human fibroblasts to heparin Anticancer Res. [Abstract],
  • 2000
  • Assimakopoulos D, Kolettas E, Zagorianakou N, Evangelou A, Skevas A, Agnantis NJ. (2000) Prognostic significance of p53 in the cancer of the larynx Anticancer Res. [Abstract],
  • 1991
  • Rosenberger RF, Gounaris EG, Kolettas E. (1991) Mechanisms responsible for the limited and immortal phenotype in cultured mammalian cells. J. Theor. Biol. ,